Cyclization of Multi Components Reactions and (Preparation, Investigation, Thermal Curves)
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Published:
2018-10-10
Keywords:
Multi Components , Cyclization, Heterocyclic ,Oxadiazole, Imidazole, Thiazole, Oxazole.
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Abstract
Many cyclic compounds were formatted via multi components reactions and cyclization reaction through many steps with ( various conditions , various starting materials , various components ), in first step , aromatic amine derivative were reacted with ammonium thiocyanate in cyclization reaction to yield 2-aminobenzothiazole derivative , which reacted with formaldehyde and benzaldehyde as a multi components reaction ., then the resulting compounds cyclized with ( semicarbazide , ortho-phenyl diamine , ortho-thiol aniline , ortho- amino phenol ). Investigation of compounds carried out through many techniques ( FT.IR , H.NMR , Mass ) – Spectra , Thermal studies
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Research Paper/Theoretical Paper/Review Paper/Short Communication Paper
How to Cite
Aljamali, N. M., Abd Allattif, N. A. A., & Abdalrahman, S. A. (2018). Cyclization of Multi Components Reactions and (Preparation, Investigation, Thermal Curves). American International Journal of Multidisciplinary Scientific Research, 2(1), 1-12. https://doi.org/10.46281/aijmsr.v2i1.190
References
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10. Subbiah,R .;Tanmoy,G.; , Tanushree,S .;Puspita, R.; Benu, P.S.;Jayatri, N. ; Avijit, D. and Tapan, K .M., Der PharmaChemica,2016,8,4,446-452.
11. NaghamMahmoodAljamali .,"Experimental Methods for Preparation of ((Mannich Bases ,Formazan , Normal and Cyclic Sulfur Compounds))".,1 Edt. , Evince pub Publishing house , 2018 ., ISBN :978-93-87905-19-1.
12. NaghamMahmoodAljamali .,"Reactions and Mechanisms".,1 Edt., IJMRA Publication ,2018 ., ISBN : 978-93-87176-25-6 .
13. KiranM. K.; Sagar, A. J.;Pramod, B. P.; Vikas, R. D. andShitalkumar, S. P. , , DerPharmaChemica,2016, 8,4,1-5.
14. Chao J .; Huia, P. X .; Lia, Z . “Synthesis and Antibacterial Activities of Novel Biphenyltetrazole Derivatives Bearing 1,3,4- Oxadiazole.” Journal of The Chinese Chemical Society,2005, 52, 539-544 539.
15. Srinivas, K. ;Srinivas, U.;Bhanuprakash, K.;Harakishore, K."Synthesis and antibacterial activity of various substituted s-triazines". Eur J Med Chem ;2006, 41, 1240-1246.
16. Woese, C.R .;Kandler, O.; Wheelis, M.L . "Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya". ,Proceedings of the National Academy of Sciences of the United States of America. , 1990, 87 ,12, 4576–9.
17. Montalbetti, C. A.; Falque, V. "Amide bond formation and peptide coupling". Tetrahedron., 2005, 61,46, 10827–10852.doi:10.1016/j.tet. 2005.08.031
18. Valeur, E.; Bradley, M. "Amide bond formation: beyond the myth of coupling compounds". Chem. Soc. Rev., 2009, 38,606–631. doi:10.1039/B701677H.
19. Nanjunda S.; Swamy, S.; Basppa, P .B.; Prabhuswamy, B.;Doreswamy, B. H. "Crystal Structure of Novel2-butyl-4-chloro-1HImidazolyl-5-Carboxaldehyde" . European Journal. of Medicinal Chemistry , 2006, 41, 531-538.3.
20. Aboraia, S. A.; Rahman, A.M.; Mahouz, M. N.;“Novel 5-(2 hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thione derivatives: Promising anticancer agents.”, Bioorganic& Medicinal Chemistry ,2006, 14, 1236–1246.
21. Mieaad Mohammed , NaghamMahmoodAljamali , Sabreen Ali Abdalrahman , WassanAlaShubber ., "Formation of Oxadiazole Derivatives Ligands from Condensation and Imination Reaction with References To Spectral Investigation, Thermal and Microbial Assay" ., Biochem. Cell. Arch. , 2018 , 18, 1, pp. 847-853.
22. NaghamMahmoodAljamali. "Synthesis and Biological Study of Hetero (Atoms and Cycles) Compounds", Der PharmaChemica, 2016, 8,6, 40-48.
23. NaghamMahmoodAljamali.; Intisar, O. "Synthesis of Sulfur Heterocyclic Compounds and Study of Expected Biological Activity" ,Research J. Pharm. and Tech., 2015, 8,9 ,1225-1242 ,DOI: 10.5958/0974-360X.2015.00224.3.
24. NaghamMahmoodAljamali .;SaherMahmood J.; Zainab MJ .; Seena K."Microbial Studying of (Thiazole ,Oxadiazole, Thiadiazole)–Derivatives on Mouth and Teeth Bacteria ", International Journal of Medical Research and Pharmaceutical Sciences, 2016, 3, 8 ,30-39 , DOI:10.5281/zenodo.61357 .
25. Rappé, M. S .; Giovannoni, S. J . "The uncultured microbial majority". Annual Review of Microbiology., 2003, 57, 369–94.
26. DeLong, E .F.; Pace, N.R . "Environmental diversity of bacteria and archaea" . Syst Biol. , 2001, 50 ,4, 470–8.
27. Rosenberg, S.M .; Slack, A . "Antibiotic-induced lateral transfer of antibiotic resistance". Trends Microbiol. , 2004, 12 ,9, 401–4.
28. Gitai, Z . "The new bacterial cell biology: moving parts and subcellular architecture". Cell, 2005 , 120 ,5, 577–86.
29. Vanita S .; Supriya, M. "Development of furfuraldehydeformazans as potential antitubercular agents " ., Der PharmaChemica, 2016,8,18, 144-148.
30. Park, S.; Park, B.; Yun, S.; Kang, H. and Yun, S. "Antimicrobial activities of honey bee venom against pathogens isolated from clinical bovine mastitis in Korea" , Planta Med., 2013, 79, , PL16.
31. Habibe,T.; Mehmet, L. A . "Electrochemical properties of 1-(o−, m−, pnitrophenyl)-3-(m−nitrophenyl)-5-phenylformazans andtheir nickel complexes" ., Turk J Chem , 2010, 34 , 465 – 479.
32. Angela, K.; Lucica, V.; Nicoleta, C . " Synthesis and structural studies of complexes of Cu, Co, Ni and Zn with isonicotinic acid hydrazide and isonicotinic acid (1-naphthylmethylene)hydrazide", J. Serb. Chem. Soc, 2010, 75 ,2, 229-242.
33. Wright, G.D. " The antibiotic resistome: the nexus of chemical and genetic diversity"., Nature Reviews Microbiology, 2007, 5, 175-186.
34. NaghamMahmoodAljamali . "Synthesis and Chemical Identification of Macro Compounds of (Thiazol and Imidazol)".,Research J. Pharm. and Tech, 2015, 8,1, 78-84., DOI : 10.5958/0974-360X.2015.00016.5 .
35. Hegazi, A.G.; Abdou, A.M. and Abd, A. F. "Evaluation of the antibacterial activity of bee venom from different sources", World Applied Sciences Journal, 2014, 30 ,3, 266-270.
36. Intisar ObaidAlfatlawi , Nuha Salman S, ZainabMahmood J , NaghamMahmoodAljamali , " Synthesis of New Organic Compounds Via Three Components Reaction with Studying of (Identification ,Thermal Behavior, Bioactivity on Bacteria of Teeth) "., Journal of Global Pharma Technology. 2017; 11, 9 ,157-164.
37. EmanH. S .,Nagham Mahmood Aljamali .,"New Azo-Thiadiazole Ligands (Preparation, Spectral, Thermal, Biochemical, Physical properties) - Studying " .,Journal of Global Pharma Technology. 2017; 11, 9 ,165.
38.Mieaad Mohamd , Nagham Mahmood Aljamali , Nadheema Abed Abbas ., " Preparation, Spectral Investigation, Thermal Analysis, Biochemical Studying of New (Oxadiazole - Five Membered Ring)-Ligands".,Journal of Global Pharmacy Technology, 2018; 10, 1, 20-29.
39. Intisar ObaidA , Eman HS , Nagham Mahmood Aljamali ., "Synthesis of (Tetrazole, Oxazepine, Azo, Imine) Ligands and Studying of Their (Organic Identification, Chromatography, Solubility, Physical, Thermal Analysis, Bio-Study) " .,Research J. Pharm. and Tech. 11, 7 , 2018 .
40. Mieaad Mohamd , Nagham Mahmood Aljamali , Wassan AlaShubber , Sabreen Ali Abdalrahman .," New Azomethine- Azo Heterocyclic Ligands Via Cyclization of Ester " ., Research J. Pharm. and Tech. 11, 6 , 2018 .,DOI: 10.5958/0974-360X.2018.00472.9 .
2. Aatesh, È. ; Kocabalkanli, A. ; Cesur, N . “Synthesis and antimicrobial activity of some 5-aryl-2-[(N,N-disubstitutedthiocarbamoylthio) acylamino]-1,3,4-oxadiazoles” , Farmaco ,1998, 53, 541-544.
3. Clark,M.S.,(2000).,"The bactericidal activity of gemifloxacin. Journal Medical microbial,Vol.49,andp:841-844.
4. Clark, W.G.; Brater, D.C.; Johnson,A.R. (1992).,"Medical pharmacology Goths. Introduction to chemotherapy mechanisms of antibacterial. International edition.
5. Cruickshank, R.; Duguid, J.P.; Matmion B.P. (1973).,"A Guide to the laboratory diagnosis and control of infections. 12Edition . London Vol:1
6. Mims H.M. (1995).Antimicrobial agents and chemo therapy .Medical microbiology Third edition.
7. Sachadev, K.N. (1989). Examination of urine clinical pathology and bacteriology seventh edition. India .
8. Yana, Y; David, M.L. (1998).,"Chromosomal B-lactamase expression and resistance to B-lactam antibiotics in proteus vulgaris and morganellamorganii. Journal Antimicrobial agents and chemotherapy, p:1385-1391.
9. Bramhananda, N. R .; Venkataramudu, B .; Ravindranath, L. K. ; Aleem, S. A. and Narendra , N. S., Der PharmaChemica,2016, 8,4,101-112.
10. Subbiah,R .;Tanmoy,G.; , Tanushree,S .;Puspita, R.; Benu, P.S.;Jayatri, N. ; Avijit, D. and Tapan, K .M., Der PharmaChemica,2016,8,4,446-452.
11. NaghamMahmoodAljamali .,"Experimental Methods for Preparation of ((Mannich Bases ,Formazan , Normal and Cyclic Sulfur Compounds))".,1 Edt. , Evince pub Publishing house , 2018 ., ISBN :978-93-87905-19-1.
12. NaghamMahmoodAljamali .,"Reactions and Mechanisms".,1 Edt., IJMRA Publication ,2018 ., ISBN : 978-93-87176-25-6 .
13. KiranM. K.; Sagar, A. J.;Pramod, B. P.; Vikas, R. D. andShitalkumar, S. P. , , DerPharmaChemica,2016, 8,4,1-5.
14. Chao J .; Huia, P. X .; Lia, Z . “Synthesis and Antibacterial Activities of Novel Biphenyltetrazole Derivatives Bearing 1,3,4- Oxadiazole.” Journal of The Chinese Chemical Society,2005, 52, 539-544 539.
15. Srinivas, K. ;Srinivas, U.;Bhanuprakash, K.;Harakishore, K."Synthesis and antibacterial activity of various substituted s-triazines". Eur J Med Chem ;2006, 41, 1240-1246.
16. Woese, C.R .;Kandler, O.; Wheelis, M.L . "Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya". ,Proceedings of the National Academy of Sciences of the United States of America. , 1990, 87 ,12, 4576–9.
17. Montalbetti, C. A.; Falque, V. "Amide bond formation and peptide coupling". Tetrahedron., 2005, 61,46, 10827–10852.doi:10.1016/j.tet. 2005.08.031
18. Valeur, E.; Bradley, M. "Amide bond formation: beyond the myth of coupling compounds". Chem. Soc. Rev., 2009, 38,606–631. doi:10.1039/B701677H.
19. Nanjunda S.; Swamy, S.; Basppa, P .B.; Prabhuswamy, B.;Doreswamy, B. H. "Crystal Structure of Novel2-butyl-4-chloro-1HImidazolyl-5-Carboxaldehyde" . European Journal. of Medicinal Chemistry , 2006, 41, 531-538.3.
20. Aboraia, S. A.; Rahman, A.M.; Mahouz, M. N.;“Novel 5-(2 hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thione derivatives: Promising anticancer agents.”, Bioorganic& Medicinal Chemistry ,2006, 14, 1236–1246.
21. Mieaad Mohammed , NaghamMahmoodAljamali , Sabreen Ali Abdalrahman , WassanAlaShubber ., "Formation of Oxadiazole Derivatives Ligands from Condensation and Imination Reaction with References To Spectral Investigation, Thermal and Microbial Assay" ., Biochem. Cell. Arch. , 2018 , 18, 1, pp. 847-853.
22. NaghamMahmoodAljamali. "Synthesis and Biological Study of Hetero (Atoms and Cycles) Compounds", Der PharmaChemica, 2016, 8,6, 40-48.
23. NaghamMahmoodAljamali.; Intisar, O. "Synthesis of Sulfur Heterocyclic Compounds and Study of Expected Biological Activity" ,Research J. Pharm. and Tech., 2015, 8,9 ,1225-1242 ,DOI: 10.5958/0974-360X.2015.00224.3.
24. NaghamMahmoodAljamali .;SaherMahmood J.; Zainab MJ .; Seena K."Microbial Studying of (Thiazole ,Oxadiazole, Thiadiazole)–Derivatives on Mouth and Teeth Bacteria ", International Journal of Medical Research and Pharmaceutical Sciences, 2016, 3, 8 ,30-39 , DOI:10.5281/zenodo.61357 .
25. Rappé, M. S .; Giovannoni, S. J . "The uncultured microbial majority". Annual Review of Microbiology., 2003, 57, 369–94.
26. DeLong, E .F.; Pace, N.R . "Environmental diversity of bacteria and archaea" . Syst Biol. , 2001, 50 ,4, 470–8.
27. Rosenberg, S.M .; Slack, A . "Antibiotic-induced lateral transfer of antibiotic resistance". Trends Microbiol. , 2004, 12 ,9, 401–4.
28. Gitai, Z . "The new bacterial cell biology: moving parts and subcellular architecture". Cell, 2005 , 120 ,5, 577–86.
29. Vanita S .; Supriya, M. "Development of furfuraldehydeformazans as potential antitubercular agents " ., Der PharmaChemica, 2016,8,18, 144-148.
30. Park, S.; Park, B.; Yun, S.; Kang, H. and Yun, S. "Antimicrobial activities of honey bee venom against pathogens isolated from clinical bovine mastitis in Korea" , Planta Med., 2013, 79, , PL16.
31. Habibe,T.; Mehmet, L. A . "Electrochemical properties of 1-(o−, m−, pnitrophenyl)-3-(m−nitrophenyl)-5-phenylformazans andtheir nickel complexes" ., Turk J Chem , 2010, 34 , 465 – 479.
32. Angela, K.; Lucica, V.; Nicoleta, C . " Synthesis and structural studies of complexes of Cu, Co, Ni and Zn with isonicotinic acid hydrazide and isonicotinic acid (1-naphthylmethylene)hydrazide", J. Serb. Chem. Soc, 2010, 75 ,2, 229-242.
33. Wright, G.D. " The antibiotic resistome: the nexus of chemical and genetic diversity"., Nature Reviews Microbiology, 2007, 5, 175-186.
34. NaghamMahmoodAljamali . "Synthesis and Chemical Identification of Macro Compounds of (Thiazol and Imidazol)".,Research J. Pharm. and Tech, 2015, 8,1, 78-84., DOI : 10.5958/0974-360X.2015.00016.5 .
35. Hegazi, A.G.; Abdou, A.M. and Abd, A. F. "Evaluation of the antibacterial activity of bee venom from different sources", World Applied Sciences Journal, 2014, 30 ,3, 266-270.
36. Intisar ObaidAlfatlawi , Nuha Salman S, ZainabMahmood J , NaghamMahmoodAljamali , " Synthesis of New Organic Compounds Via Three Components Reaction with Studying of (Identification ,Thermal Behavior, Bioactivity on Bacteria of Teeth) "., Journal of Global Pharma Technology. 2017; 11, 9 ,157-164.
37. EmanH. S .,Nagham Mahmood Aljamali .,"New Azo-Thiadiazole Ligands (Preparation, Spectral, Thermal, Biochemical, Physical properties) - Studying " .,Journal of Global Pharma Technology. 2017; 11, 9 ,165.
38.Mieaad Mohamd , Nagham Mahmood Aljamali , Nadheema Abed Abbas ., " Preparation, Spectral Investigation, Thermal Analysis, Biochemical Studying of New (Oxadiazole - Five Membered Ring)-Ligands".,Journal of Global Pharmacy Technology, 2018; 10, 1, 20-29.
39. Intisar ObaidA , Eman HS , Nagham Mahmood Aljamali ., "Synthesis of (Tetrazole, Oxazepine, Azo, Imine) Ligands and Studying of Their (Organic Identification, Chromatography, Solubility, Physical, Thermal Analysis, Bio-Study) " .,Research J. Pharm. and Tech. 11, 7 , 2018 .
40. Mieaad Mohamd , Nagham Mahmood Aljamali , Wassan AlaShubber , Sabreen Ali Abdalrahman .," New Azomethine- Azo Heterocyclic Ligands Via Cyclization of Ester " ., Research J. Pharm. and Tech. 11, 6 , 2018 .,DOI: 10.5958/0974-360X.2018.00472.9 .